Boyle Heights is the easternmost neighborhood in L.A. Noire's rendition of Los Angeles. A small industrial district located to the east of the Los Angeles River, the neighborhood can only be reached using one of the five bridges that span over the river. One notable locale in Boyle Heights is a military training base, located just north of the Olympic Boulevard Bridge, better known as the 6th Street Viaduct.

Boyle Heights is only visited once during a case; this is at the end of the very first case Upon Reflection when Cole Phelps visits Errol Schroeder, who resides in Boyle Heights.